Renal Transplantation in the Presence of a Positive Cytotoxic Antibody.

W ITH THE EXCEPTION of the B cell autoantibodies,' the positive crossmatch is associated with the development of hyperacute rejection, and contraindication to clinical renal transplantation.2•6 The mere historical presence of cytotoxic antibodi.es, is not a contraindication, provided the cross match with a current serum (CS) at transplantation is negative.7,s In addition the occurrence of hyperacute rejection in the presence of a negative cytotoxic crossmatch,5,9 prompts the ques: tion of the limitations of the technique in the opposite direction. This report refers to our experience with clinical renal transplantation in the presence of a doubtful or weakly positive crossmatch with CS.